Phenolic Profile, Fatty Acid and Essential Oil Composition Analysis and Antioxidant, Antialzheimer and Antibacterial Activities of Verbascum flavidum Extracts

Boga M., Ertas A., Hasimi N., DEMİRCİ S. , Yilmaz M. A. , Temel H., ...Daha Fazla

CHIANG MAI JOURNAL OF SCIENCE, cilt.43, ss.1089-1100, 2016 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 43 Konu: 5
  • Basım Tarihi: 2016
  • Sayfa Sayıları: ss.1089-1100


This paper is the first report about phytochemical analysis with LC-MS/MS and biological activities of Verbascum flavidum (Boiss.) Freyn & Bornm. Rutin (1077.09 +/- 77.47 mu g analyte/g extract) and chlorogenic acid (1012.42 +/- 97.18 mu g analyte/g extract) were determined as the most abundant phenolics in V. flavidum. The main components of fatty acid were found to be palmitic (30.3%) and oleic acids (17.9%); while the major essential oils were determined as arachidic acid (16.4%) and alpha-selinene (8.9%) by GC-MS analysis. In DPPH free radical scavenging activity the methanol extract showed higher activity than BHT with 72.62% inhibition at 100 mu g/mL concentration. The methanol and water extracts of V. flavidum showed 86.01 and 87.39 % inhibition in ABTS cation radical scavenging assay at 100 mu g/mL concentration, respectively. The methanol extract showed moderate activity against E. coli with 250 +/- 0.3 MIC value and with 15 mm inhibition zone diameter at 30 mg/mL concentration.