Tezin Türü: Yüksek Lisans
Tezin Yürütüldüğü Kurum: Çukurova Üniversitesi, Bağımlılık Ve Adli Bilimler Enstitüsü, Adli Bilimler, Türkiye
Tezin Onay Tarihi: 2023
Tezin Dili: İngilizce
Öğrenci: WAZODI AMOSI
Danışman: Mehmet Bertan Yılmaz
Özet:
The forensic analysis of Y chromosome SNPs has become
a useful tool in understanding the genetic diversity of various populations. The
identification of unique Y chromosome SNPs is useful in Forensic investigations
of cases where a male DNA profile is needed, such as in cases of sexual
assault, paternity testing, or missing persons investigations. In this
research, a forensic analysis of the Y chromosome SNPs from 32 unrelated male
individuals of the Elgon population in Eastern Uganda using the Next Generation
Sequencing Technology (NGS) and the
Ion AmpliSeq HID Y-SNP Research Panel v1 primer
pool. Using the Y-leaf
analysis tool, our results showed that the Elgon population exhibited a high
degree of genetic diversity of 40.6% which is characteristic of many African
populations. Thirteen (13) unique Y chromosome SNPs (Haplogroups) that could
serve as useful genetic markers for forensic analysis and population genetics
studies were identified in this study. The haplogroups originate from the major
three Haplogroups A, B and E typical of the African Population and the
haplogroups were A1b, A-M13, B-M5844, B-Y12200, B-Y275213, E-M41, E-Z830,
E-V22, E-U175, E-M4254, E-U174, E-L514 and E-U290. Haplogroup E-U174 was
observed in highest frequency 24.24% in Bagisu only and haplogroups B-Y275213,
E-Z830 and E-U290 were observed in Sabiny only. Other haplogroups were shared
in both. Overall, this research provides valuable insights into the genetic
makeup of the Elgon population and underscores the importance of Y chromosome
SNPs in forensic analysis and population genetics research. By analyzing SNPs
on the Y chromosome, forensic scientists can develop a genetic profile that can
be used to identify the male contributors to a DNA sample. However, further
studies should be conducted to investigate the genetic diversity of other
populations in Uganda using Y chromosome SNPs with a large sample size as this
will help to fully understand the genetic diversity of the country.