Elution of residual monomers from dental composite resins

Sonkaya E. , Bakır Ş.

Biomedical Research, vol.31, no.5, pp.148-154, 2020 (Refereed Journals of Other Institutions)

  • Publication Type: Article / Article
  • Volume: 31 Issue: 5
  • Publication Date: 2020
  • Title of Journal : Biomedical Research
  • Page Numbers: pp.148-154


The biocompatibility of composite resins decreases with the increase of released monomer since they are cytotoxic on pulp or living tissues. Commercially used composites should be chosen according to their biocompatibility to not jeopardize the patient’s health. Analysis of the composite biocompatibility and determination of the monomers elution of four different composite resin materials with nanofiller content is completed in the study to investigate if there is a difference and the most possible healthy way of usage.

The amount of Bis-GMA, UDMA, and TEGDMA released from four different composite resins was measured on three different days using the HPLC. Four groups (n=10, diameter: 5 mm, thickness: 2 mm) of each material were prepared. Samples were placed in 75% ethanol water. On days 1, 15, and 30, 1 mL samples were taken for measurement. A total of 120 samples’ findings were analyzed statistically.

Bis-GMA and UDMA were released from all the materials used in the study. There were significant differences in the total monomer release of all composite resins in terms of time (P=0.001). Tetric Evoceram is the most residual monomer-releasing composite in experiment groups. The maximum amount of monomer release for all three monomers was on the 15th day. In order to reduce concerns about toxicity, taking measures to protect the pulp for example using cavity liners and bases especially in case of having less than 0.5 mm thickness of dentin. There is a need for these results to be supported by further clinical studies.

Keywords: Nanofiller Composite Resin, Residual Monomer, High-Performance Liquid Chromatography, Biocompatibility, Cytotoxicity.