Mannose-Binding Lectin 2 Gene Polymorphism in PANDAS Patients

GÜL ÇELİK, GONCA; TAŞ ARSLAN, DİDEM; YOLGA TAHİROĞLU, AYŞEGÜL; ERKEN, EREN; SEYDAOĞLU, GÜLŞAH; Ray, Perihan; AVCI, AYŞE

doi:10.29399/npa.22811

Mannose-Binding Lectin 2 Gene Polymorphism in PANDAS Patients

GÜL ÇELİK G., TAŞ ARSLAN D., YOLGA TAHİROĞLU A., ERKEN E., SEYDAOĞLU G., Ray P. C., ...Daha Fazla

NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY, cilt.56, sa.2, ss.99-105, 2019 (SCI-Expanded, Scopus, TRDizin)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 56 Sayı: 2
Basım Tarihi: 2019
Doi Numarası: 10.29399/npa.22811
Dergi Adı: NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
Sayfa Sayıları: ss.99-105
Anahtar Kelimeler: Mannose-binding-lectin2 gene, obsessive-compulsive disorder, pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections, RESPIRATORY-TRACT INFECTIONS, OBSESSIVE-COMPULSIVE SCALE, STREPTOCOCCAL INFECTIONS, DISORDERS, RELIABILITY, CHILDREN, SUSCEPTIBILITY, AGE
Çukurova Üniversitesi Adresli: Evet

Özet

Introduction: Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS), a subgroup of obsessive-compulsive disorder (OCD), has received much attention even though the specific underlying mechanisms remain unknown. Mannose-binding lectin (MBL) is a key factor in the innate immune response. The aim of this study was to investigate the role of MBL2 gene polymorphisms in pediatric OCD patients diagnosed as PANDAS, PANDAS-Variant and non-PANDAS.