The analysis of lncRNA HOTAIR rs12826786 C > T polymorphism and gastric cancer susceptibility in a Turkish population: lack of any association in a hospital-based case-control study

Ulger Y., Dadas E., Kaya B. Y., Sumbul A. T., Genc A., Bayram S.

IRISH JOURNAL OF MEDICAL SCIENCE, vol.186, no.4, pp.859-865, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 186 Issue: 4
  • Publication Date: 2017
  • Doi Number: 10.1007/s11845-017-1596-x
  • Journal Name: IRISH JOURNAL OF MEDICAL SCIENCE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.859-865
  • Çukurova University Affiliated: No

Abstract

The HOX transcript antisense intergenic RNA (HOTAIR), a well-known long noncoding RNA (lncRNA), has been widely identified to participate in pathogenesis of multiple cancers. An aberrant up-regulation and biological functions have been observed in gastric cancer (GC). A common single nucleotide polymorphism (SNP) (rs12826786 C > T) at the HOTAIR has been reported to influence HOTAIR expression, but its association with GC has yet to be investigated in Turkish population.