The analysis of lncRNA HOTAIR rs12826786 C > T polymorphism and gastric cancer susceptibility in a Turkish population: lack of any association in a hospital-based case-control study


Ulger Y. , Dadas E., Kaya B. Y. , Sumbul A. T. , Genc A., Bayram S.

IRISH JOURNAL OF MEDICAL SCIENCE, cilt.186, sa.4, ss.859-865, 2017 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 186 Konu: 4
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1007/s11845-017-1596-x
  • Dergi Adı: IRISH JOURNAL OF MEDICAL SCIENCE
  • Sayfa Sayıları: ss.859-865

Özet

The HOX transcript antisense intergenic RNA (HOTAIR), a well-known long noncoding RNA (lncRNA), has been widely identified to participate in pathogenesis of multiple cancers. An aberrant up-regulation and biological functions have been observed in gastric cancer (GC). A common single nucleotide polymorphism (SNP) (rs12826786 C > T) at the HOTAIR has been reported to influence HOTAIR expression, but its association with GC has yet to be investigated in Turkish population.