Biological properties and conformational studies of amphiphilic Pd(II) and Ni(II) complexes bearing functionalized aroylaminocarbo-N-thioylpyrrolinate units

Poyraz S., Belveren S., AYDINOĞLU S., Ulger M., de Cozar A., Retamosa M. d. G., ...Daha Fazla

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, cilt.17, ss.2812-2821, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17
  • Basım Tarihi: 2021
  • Doi Numarası: 10.3762/bjoc.17.192
  • Dergi Adı: BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Aquatic Science & Fisheries Abstracts (ASFA), Biotechnology Research Abstracts, Chemical Abstracts Core, Directory of Open Access Journals
  • Sayfa Sayıları: ss.2812-2821
  • Anahtar Kelimeler: antituberculosis, bidentate ligands, DFT, nickel, palladium, ANTIMICROBIAL ACTIVITY, CYTOTOXIC ACTIVITY, ANTIBACTERIAL, ANTIFUNGAL, LIGANDS
  • Çukurova Üniversitesi Adresli: Evet

Özet

A series of novel palladium(II) and nickel(II) complexes of multifunctionalized aroylaminocarbo-N-thioylpyrrolinates were synthe-sized and characterized by analytical and spectroscopic techniques. The biological properties of the freshly prepared compounds were screened against S. aureus, B. subtilis, A. hydrophila, E. coli, and A. baumannii bacteria and antituberculosis activity against M. tuberculosis H37Rv strains. Also, the antifungal activity was studied against C. albicans, C. tropicalis, and C. glabrata standard strains. A deep conformational survey was monitored using DFT calculations with the aim to explain the importance of the final conformation in the biological experimental results.