Biological properties and conformational studies of amphiphilic Pd(II) and Ni(II) complexes bearing functionalized aroylaminocarbo-N-thioylpyrrolinate units


Poyraz S., Belveren S., AYDINOĞLU S. , Ulger M., de Cozar A., Retamosa M. d. G. , ...More

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, vol.17, pp.2812-2821, 2021 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17
  • Publication Date: 2021
  • Doi Number: 10.3762/bjoc.17.192
  • Title of Journal : BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
  • Page Numbers: pp.2812-2821
  • Keywords: antituberculosis, bidentate ligands, DFT, nickel, palladium, ANTIMICROBIAL ACTIVITY, CYTOTOXIC ACTIVITY, ANTIBACTERIAL, ANTIFUNGAL, LIGANDS

Abstract

A series of novel palladium(II) and nickel(II) complexes of multifunctionalized aroylaminocarbo-N-thioylpyrrolinates were synthe-sized and characterized by analytical and spectroscopic techniques. The biological properties of the freshly prepared compounds were screened against S. aureus, B. subtilis, A. hydrophila, E. coli, and A. baumannii bacteria and antituberculosis activity against M. tuberculosis H37Rv strains. Also, the antifungal activity was studied against C. albicans, C. tropicalis, and C. glabrata standard strains. A deep conformational survey was monitored using DFT calculations with the aim to explain the importance of the final conformation in the biological experimental results.