In this study, salinity and drought responses of 42 melon genotypes were investigated in early plant growth stage. The plants were grown in vermiculite culture with 200 mM NaCl for salinity stress and irrigation was stopped gradually for terminal-drought stress. Control plants without stress were also grown. Young plant stage (29 day-old plant) was used for screening studies. In order to identify tolerant and susceptible melon genotypes, some physiological measurements and analysis were realized: 0-5 scale evaluation for the symptomatic appearance of the plants, shoot fresh and dry weights, root fresh and dry weights, leaf number per plant, leaf area, SPAD-Chlorophyll meter reading, membrane injury index, leaf relative water content, leaf water potential, leaf osmotic potential, stomata conductance, leaf temperature, Na, K, Ca, and Cl concentrations of the shoot and root samples. For each parameter, differences in salinity and drought stresses compared to control were calculated. At the end of the study, large variations were determined in melon genotypes for their salinity and drought responses. Forty-two melon genotypes were classified as tolerant, mild tolerant and susceptible.