Development of starch based mucoadhesive vaginal drug delivery systems for application in veterinary medicine

GÖK M. K., PABUCCUOĞLU S. K., Demir K., Cirit Ü., PABUCCUOĞLU S., CEVHER E., ...Daha Fazla

CARBOHYDRATE POLYMERS, cilt.136, ss.63-70, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 136
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1016/j.carbpol.2015.08.079
  • Dergi Adı: CARBOHYDRATE POLYMERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.63-70
  • Çukurova Üniversitesi Adresli: Hayır

Özet

The aim of this study was to prepare and evaluate the mucoadhesive, biocompatible and biodegradable progesterone containing vaginal tablets based on modified starch copolymers for the estrus synchronization of ewes. Starch-graft-poly( acrylic acid) copolymers (S-g-PAA) were synthesized and characterized. The vaginal tablets were fabricated with S-g-PAA and their equilibrium swelling degree (Qe) and matrix erosion (ME%) were determined in lactate buffer solution. In vitro, mucoadhesive properties of the tablets were investigated by using ewe vaginal mucosa and in vivo residence time were also investigated. In vitro and in vivo progesterone release profiles from the tablets were compared with two commercial products. Tablet formulation containing wheat starch based grafted copolymer (WS-g-PAA)(gc) indicated promising results and might be convenient as an alternative product to the commercial products in veterinary medicine. (C) 2015 Elsevier Ltd. All rights reserved.