Akademik Veri Yönetim Sistemi
INSAC World Health Sciences, Doç. Dr. Mehmet DALKILIÆ Dr. Öğretim Üyesi Hale KÖKSOY, Editör, Gece Kitaplığı, Ankara, ss.926-938, 2022
Every living species has a unique set of
chromosomes that carry the necessary and sufficient genetic
information to survive and reproduce. In order for living organisms
to reproduce, it is very important that they correctly transfer their genetic
information to new generations of cells. Here,
defects in DNA replication,
defects in cell cycle progression and
control points, repair of DNA damage, correct
and balanced separation of chromosomes are
important. An error in any of these genetic pathways can lead to cell death or the formation of cells with altered
genetic information. Since this situation changes
the expression of genetic information significantly, it causes the development of pathological defects
in the embryo or organism. The
numerical chromosome abnormalities (NCAs) occurring in the organism are defined as aneuploidy. Cancer-related genetic
events; it is unknown how activation
of oncogenes and inactivation of tumor suppressors occurs with genes on the X chromosome. The molecular basis for the oncogenic
effects of doubling the copy number of the genes that are affected is also unclear.
But, the X-chromosome aneusomy is thought
to have a possible role in
neoplastic transformation. The X-chromosome monosomy provides a unique genetic gain for the expression of common
cancer-causing genetic events. This
section explains the relationship between cancer biology and the X chromosome.