Rotaviruses are the most common cause of severe gastroenteritis in infants and children. Rotaviruses are responsible for approximately 40% of all diarrheal hospitalizations among children under 5 years of age worldwide. Rotavirus, which is known as democratic virus, occurs with similar frequency in both developed and developing countries regardless of the hygiene conditions. Almost all children up to 5 years of age are infected with rotavirus at least once. But the majority of death cases towing to rotaviruses occur in children from resource-poor countries. Many investigators have reported that previous rotavirus infections protect against severe disease associated with reinfection. For this reason, vaccination in the early period of infancy is the most important method for protection against severe rotavirus infections and death. World Health Organization recommends rotavirus vaccination. After the introduction of rotavirus vaccines, significant reduction has been seen in morbidity and mortality because of rotaviruses. Rotavirus vaccine administration is particularly important in developing countries where majority of death cases are observed.