Reversible posterior leukoencephalopathy syndrome (RPLS) describes a syndrome with potentially reversible specific imaging appearance and symptomatology, which is associated with varied causes including hypertension, eclampsia and preeclampsia, immunosuppressive drugs, thrombocytopenic syndromes, and various causes of renal failure. The most common clinical presentations are headaches, mental abnormalities, seizures, and visual disturbances. The typical neuroimaging findings in RPLS include the parietal and occipital lobes. Involvement of additional areas of the brain or main lesions in areas other than the parieto-occipital lobes have been also reported in patients with RPLS. In this report, we describe a 25-year-old man with uremia presented with reversible quadriparesis and lesions in anterior circulation areas of the cerebral hemisphere sparing parieto-occipital regions on magnetic resonance imaging.