No significant increase in chromosome aberrations and sister chromatid exchanges in cultured human lymphocytes treated with spiramycin

RENCÜZOĞULLARI, Eyyüp; Ila, HASAN; Topaktas, MEHMET; KAYRALDIZ, Ahmet; BUDAK, Songül; ARSLAN, Mehmet

doi:10.1002/tcm.1038

No significant increase in chromosome aberrations and sister chromatid exchanges in cultured human lymphocytes treated with spiramycin

Atıf İçin Kopyala

RENCÜZOĞULLARI E., Ila H. B., Topaktas M., KAYRALDIZ A., BUDAK S., ARSLAN M.

TERATOGENESIS CARCINOGENESIS AND MUTAGENESIS, cilt.22, sa.1, ss.51-58, 2002 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 22 Sayı: 1
Basım Tarihi: 2002
Doi Numarası: 10.1002/tcm.1038
Dergi Adı: TERATOGENESIS CARCINOGENESIS AND MUTAGENESIS
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.51-58
Çukurova Üniversitesi Adresli: Evet

Özet

In this study, the chromosomal aberrations (CAs) and sister chromatid exchanges (SCEs) were investigated in human lymphocytes treated with spiramycin antibiotic (trade name, rovamycin). Spiramycin did not induce the CAs and SCEs, and also did not decrease the mitotic index (MI). However, spiramycin decreased the replication index (RI) only at 48 h treatment times. (C) 2002 Wiley-Liss, Inc.