No significant increase in chromosome aberrations and sister chromatid exchanges in cultured human lymphocytes treated with spiramycin


RENCÜZOĞULLARI E., Ila H. B. , Topaktas M. , KAYRALDIZ A., BUDAK S., ARSLAN M.

TERATOGENESIS CARCINOGENESIS AND MUTAGENESIS, cilt.22, ss.51-58, 2002 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 22 Konu: 1
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1002/tcm.1038
  • Dergi Adı: TERATOGENESIS CARCINOGENESIS AND MUTAGENESIS
  • Sayfa Sayıları: ss.51-58

Özet

In this study, the chromosomal aberrations (CAs) and sister chromatid exchanges (SCEs) were investigated in human lymphocytes treated with spiramycin antibiotic (trade name, rovamycin). Spiramycin did not induce the CAs and SCEs, and also did not decrease the mitotic index (MI). However, spiramycin decreased the replication index (RI) only at 48 h treatment times. (C) 2002 Wiley-Liss, Inc.