TERATOGENESIS CARCINOGENESIS AND MUTAGENESIS, vol.22, no.1, pp.51-58, 2002 (SCI-Expanded)
In this study, the chromosomal aberrations (CAs) and sister chromatid exchanges (SCEs) were investigated in human lymphocytes treated with spiramycin antibiotic (trade name, rovamycin). Spiramycin did not induce the CAs and SCEs, and also did not decrease the mitotic index (MI). However, spiramycin decreased the replication index (RI) only at 48 h treatment times. (C) 2002 Wiley-Liss, Inc.