No significant increase in chromosome aberrations and sister chromatid exchanges in cultured human lymphocytes treated with spiramycin

RENCÜZOĞULLARI E., Ila H. B., Topaktas M., KAYRALDIZ A., BUDAK S., ARSLAN M.

TERATOGENESIS CARCINOGENESIS AND MUTAGENESIS, vol.22, no.1, pp.51-58, 2002 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 1
  • Publication Date: 2002
  • Doi Number: 10.1002/tcm.1038
  • Journal Name: TERATOGENESIS CARCINOGENESIS AND MUTAGENESIS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.51-58
  • Çukurova University Affiliated: Yes

Abstract

In this study, the chromosomal aberrations (CAs) and sister chromatid exchanges (SCEs) were investigated in human lymphocytes treated with spiramycin antibiotic (trade name, rovamycin). Spiramycin did not induce the CAs and SCEs, and also did not decrease the mitotic index (MI). However, spiramycin decreased the replication index (RI) only at 48 h treatment times. (C) 2002 Wiley-Liss, Inc.