Lycopene in the Prevention of Radiation-Induced Esophagitis


COŞKUN H., ANDİÇ F. , DAĞLIOĞLU Y. K. , DORAN F. , Sahin K., TUNALI C. , et al.

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, cilt.69, ss.319-329, 2017 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 69 Konu: 2
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1080/01635581.2017.1265133
  • Dergi Adı: NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
  • Sayfa Sayısı: ss.319-329

Özet

We aimed to research whether lycopene (L) could prevent radiation-induced acute esophageal toxicity in Wistar albino rats. 60 rats were placed in five groups as follows: control, L, radiotherapy (RT), L before RT (L + RT), and L before and after RT (L + RT + L). 6mg/kg bw/day L was administered 7days in the L group, 7days before RT in the L + RT group, and 7days before and after in the L + RT + L group. 35Gy thoracic RT was performed. Serum L levels were measured, and the esophagi were evaluated histopathologically for intraepithelial degenerative changes-necrosis, vacuole formation, inflammation, regeneration-mitosis, and subepithelial bulla formation. L levels were significantly higher in the L receiving groups. All histopathologic results were significantly worse in the RT group than in the none-RT groups. The L + RT and the L + RT + L groups had better results than the RT group. Grade 2-3 degenerative changes-necrosis and vacuole formation were significantly lesser in the L + RT and the L + RT + L groups than those in the RT group. There was a trend toward decreased subepithelial bulla formation and inflammation in the L + RT and the L + RT + L groups compared to the RT group. Regeneration-mitosis was insignificantly lesser in the L + RT and significantly fewer in the L + RT + L groups than that in the RT group.