Lycopene in the Prevention of Radiation-Induced Esophagitis

COŞKUN H., ANDİÇ F. , DAĞLIOĞLU Y. K. , DORAN F. , Sahin K., TUNALI C. , ...More

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, vol.69, no.2, pp.319-329, 2017 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 69 Issue: 2
  • Publication Date: 2017
  • Doi Number: 10.1080/01635581.2017.1265133
  • Page Numbers: pp.319-329


We aimed to research whether lycopene (L) could prevent radiation-induced acute esophageal toxicity in Wistar albino rats. 60 rats were placed in five groups as follows: control, L, radiotherapy (RT), L before RT (L + RT), and L before and after RT (L + RT + L). 6mg/kg bw/day L was administered 7days in the L group, 7days before RT in the L + RT group, and 7days before and after in the L + RT + L group. 35Gy thoracic RT was performed. Serum L levels were measured, and the esophagi were evaluated histopathologically for intraepithelial degenerative changes-necrosis, vacuole formation, inflammation, regeneration-mitosis, and subepithelial bulla formation. L levels were significantly higher in the L receiving groups. All histopathologic results were significantly worse in the RT group than in the none-RT groups. The L + RT and the L + RT + L groups had better results than the RT group. Grade 2-3 degenerative changes-necrosis and vacuole formation were significantly lesser in the L + RT and the L + RT + L groups than those in the RT group. There was a trend toward decreased subepithelial bulla formation and inflammation in the L + RT and the L + RT + L groups compared to the RT group. Regeneration-mitosis was insignificantly lesser in the L + RT and significantly fewer in the L + RT + L groups than that in the RT group.