Caffeic acid phenethyl ester (CAPE) supplemented St. Thomas' hospital cardioplegic solution improves the antioxidant defense system of rat myocardium during ischemia-reperfusion injury

Ozeren M., Sucu N., Tamer L., Aytacoglu B., Bayri O., DÖNDAŞ H. A., ...Daha Fazla

PHARMACOLOGICAL RESEARCH, cilt.52, sa.3, ss.258-263, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 52 Sayı: 3
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1016/j.phrs.2005.04.002
  • Dergi Adı: PHARMACOLOGICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.258-263
  • Anahtar Kelimeler: caffeic acid phenethyl ester, St. Thomas solution, antioxidants, myocardial reperfusion injury, scavenger, OXIDATIVE STRESS, ALPHA-TOCOPHEROL, NITRIC-OXIDE, MYELOPEROXIDASE
  • Çukurova Üniversitesi Adresli: Hayır

Özet

Background and aim of study: Cardioplegic arrest remains the method of choice for myocardial protection in cardiac surgery. Caffeic acid phenethyl ester (CAPE) prevents lipid peroxidation induced by ischemia-reperfusion injury and has a potent antioxidant property. We investigated the advantages of CAPE supplemented cardioplegic solution (St. Thomas' Hospital cardioplegic solution No.: 2) on the antioxidant defense system of myocardium against ischemia-reperfusion injury.