Caffeic acid phenethyl ester (CAPE) supplemented St. Thomas' hospital cardioplegic solution improves the antioxidant defense system of rat myocardium during ischemia-reperfusion injury

Ozeren, M; Sucu, N; Tamer, L; Aytacoglu, B; Bayri, O; DÖNDAŞ, HACI; Ayaz, L; Dikmengil, M

doi:10.1016/j.phrs.2005.04.002

Caffeic acid phenethyl ester (CAPE) supplemented St. Thomas' hospital cardioplegic solution improves the antioxidant defense system of rat myocardium during ischemia-reperfusion injury

Ozeren M., Sucu N., Tamer L., Aytacoglu B., Bayri O., DÖNDAŞ H. A., ...Daha Fazla

PHARMACOLOGICAL RESEARCH, cilt.52, sa.3, ss.258-263, 2005 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 52 Sayı: 3
Basım Tarihi: 2005
Doi Numarası: 10.1016/j.phrs.2005.04.002
Dergi Adı: PHARMACOLOGICAL RESEARCH
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.258-263
Anahtar Kelimeler: caffeic acid phenethyl ester, St. Thomas solution, antioxidants, myocardial reperfusion injury, scavenger, OXIDATIVE STRESS, ALPHA-TOCOPHEROL, NITRIC-OXIDE, MYELOPEROXIDASE
Çukurova Üniversitesi Adresli: Hayır

Özet

Background and aim of study: Cardioplegic arrest remains the method of choice for myocardial protection in cardiac surgery. Caffeic acid phenethyl ester (CAPE) prevents lipid peroxidation induced by ischemia-reperfusion injury and has a potent antioxidant property. We investigated the advantages of CAPE supplemented cardioplegic solution (St. Thomas' Hospital cardioplegic solution No.: 2) on the antioxidant defense system of myocardium against ischemia-reperfusion injury.