Caffeic acid phenethyl ester (CAPE) supplemented St. Thomas' hospital cardioplegic solution improves the antioxidant defense system of rat myocardium during ischemia-reperfusion injury

Ozeren M., Sucu N., Tamer L., Aytacoglu B., Bayri O., DÖNDAŞ H. A., ...More

PHARMACOLOGICAL RESEARCH, vol.52, no.3, pp.258-263, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 52 Issue: 3
  • Publication Date: 2005
  • Doi Number: 10.1016/j.phrs.2005.04.002
  • Journal Name: PHARMACOLOGICAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.258-263
  • Keywords: caffeic acid phenethyl ester, St. Thomas solution, antioxidants, myocardial reperfusion injury, scavenger, OXIDATIVE STRESS, ALPHA-TOCOPHEROL, NITRIC-OXIDE, MYELOPEROXIDASE
  • Çukurova University Affiliated: No

Abstract

Background and aim of study: Cardioplegic arrest remains the method of choice for myocardial protection in cardiac surgery. Caffeic acid phenethyl ester (CAPE) prevents lipid peroxidation induced by ischemia-reperfusion injury and has a potent antioxidant property. We investigated the advantages of CAPE supplemented cardioplegic solution (St. Thomas' Hospital cardioplegic solution No.: 2) on the antioxidant defense system of myocardium against ischemia-reperfusion injury.