Fludarabine as the possible cause of acute myelofibrosis

Paydas S., Disel U., Yavuz S., Ergin M.

HEMATOLOGY JOURNAL, vol.5, no.3, pp.283-284, 2004 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Letter
  • Volume: 5 Issue: 3
  • Publication Date: 2004
  • Doi Number: 10.1038/sj.thj.6200394
  • Journal Name: HEMATOLOGY JOURNAL
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier
  • Page Numbers: pp.283-284
  • Çukurova University Affiliated: Yes

Abstract

Fludarabine (F) is a nucleoside analog and is used for
the treatment ofmalignant lymphoproliferative disor-ders. In recent years, it has been used in conditioning
regimens ofmini-allotransplantations and resistant–
relapse acute leukemias. However, this compound has
some side effects and some of them may be life-threatening. Here, we report a case with myelofibrosis
(MF) and discuss its possible mechanism associated with
the use ofF