FREQUENCY OF VENOUS THROMBOSIS RELATED DNA POLYMORPHISMS IN A HEALTHY TURKISH POPULATION


MENZILETOGLU-YILDIZ S., KOCAMAZ D. , Nyrahabimana F., GOZET Y., GÜVENÇ B.

FRESENIUS ENVIRONMENTAL BULLETIN, cilt.27, ss.4797-4801, 2018 (SCI İndekslerine Giren Dergi) identifier

  • Cilt numarası: 27 Konu: 7
  • Basım Tarihi: 2018
  • Dergi Adı: FRESENIUS ENVIRONMENTAL BULLETIN
  • Sayfa Sayıları: ss.4797-4801

Özet

Environmental and genetic factors play important role for the development of venous thromboembolic diseases. This study investigated the prevalence coagulation factor V Leiden (FVL) and factor II G20210A (FII) in a sample (N=96) of the Turkish population depending on age and weight. Participants were stratified into two age groups: 20-39 years, 40-59 years and their body mass index: normal (<24.9), obese (>25). The heterozygous FII genotype was identified in 2 (8.33%) of normal donors in 20-30 years while it was found in 1 (4.16%) of obese donors in 40-59 years. The mutant homozygous FVL genotype was found in 1 (4.16%) of obese donors in 20-30 years. The distribution of allele and genotype frequencies of FVL and FII polymorphisms did not differ significantly between normal and obese groups. Also, the frequencies of carriage rates of FVL and FII polymorphisms in 20-39 and 40-59 years were similar. In our study, observed FII allelic frequencies are higher than other healthy populations whereas the prevalence of factor V Leiden gene polymorphism was found to be consistent. Knowledge of the prevalence of these coagulation factor variations in a given population may contribute to the design of effective preventive measures against venous thrombosis.