Evaluating Choroidal Characteristics in Systemic Sclerosis Using Enhanced Depth Imaging Optical Coherence Tomography

ESEN E., Tas D. A., SIZMAZ S., TÜRK İ., ÜNAL İ., Demircan N.

OCULAR IMMUNOLOGY AND INFLAMMATION, vol.25, no.3, pp.356-362, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 25 Issue: 3
  • Publication Date: 2017
  • Doi Number: 10.3109/09273948.2015.1129424
  • Journal Name: OCULAR IMMUNOLOGY AND INFLAMMATION
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.356-362
  • Keywords: Central macular thickness, choroidal thickness, optical coherence tomography, systemic sclerosis, vasculopathy, FLUORESCEIN ANGIOGRAPHY, VASCULAR DYSREGULATION, SCLERODERMA, MANIFESTATIONS, CHOROIDOPATHY, ENDOTHELIN-1, ASSOCIATION, THICKNESS, SUBSETS
  • Çukurova University Affiliated: Yes

Abstract

Purpose: To evaluate choroidal thickness (CT) and investigate the involvement of choroidal circulation in patients with systemic sclerosis (SSc).Methods: A total of 120 eyes of 60 SSc patients and 60 eyes of 30 healthy controls were evaluated. CT measurements were performed at the subfoveal region, 1000 mu m nasal and 1000 mu m temporal to the fovea, using enhanced depth imaging optical coherence tomography. CT measurements were compared between the patients and controls.Results: The average subfoveal, parafoveal nasal and parafoveal temporal CT were significantly thinner in SSc patients when compared with healthy controls (297.77 60.8 mu m vs 339.8 +/- 50.4 mu m; 267.32 +/- 51.1 mu m vs 308.65 +/- 49.9 mu m; 270.63 +/- 46.3 mu m vs 309.22 +/- 42.4 mu m, respectively; p<0.001 for all).Conclusions: Reduced CT in SSc patients supports the hypothesis of widespread vascular injury, including the ocular microcirculation.