Melatonin status in pediatric intensive care patients with sepsis

Bagci S., Horoz O. O., Yildizdas D., Reinsberg J., Bartmann P., Mueller A.

PEDIATRIC CRITICAL CARE MEDICINE, cilt.13, sa.2, 2012 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 13 Sayı: 2
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1097/pcc.0b013e3182191dc4
  • Dergi Adı: PEDIATRIC CRITICAL CARE MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: melatonin, sepsis, septic shock, children, intensive care, CIRCADIAN-RHYTHM, SEPTIC SHOCK, RAT MODEL, CYTOCHROME-P450, SECRETION, METABOLISM, PROTECTS, PUBERTY, INJURY
  • Çukurova Üniversitesi Adresli: Evet

Özet

Objective: Considering the potential immunomodulatory role of melatonin and its direct antioxidant activity, disturbances of the melatonin secretion pattern in the septic conditions could be particularly unfavorable. The aim of this study was to evaluate the nocturnal melatonin concentration and total 24-hr excretion of 6-sulfatoxymelatoninsulfate, melatonin's major urinary metabolite, in children with sepsis in the pediatric intensive care unit.