A RANDOMIZED STUDY COMPARING CYCLOPHOSPHAMIDE, DOXORUBICIN, VINCRISTINE (CAV) WITH CYCLOPHOSPHAMIDE, ETOPOSIDE, VINCRISTINE, METHOTREXATE (CEVM) IN PATIENTS WITH SMALL-CELL LUNG-CANCER

ERKISI M., UNSAL M., TUNALI C., BURGUT R., DORAN F.

JOURNAL OF CHEMOTHERAPY, cilt.5, sa.1, ss.56-59, 1993 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 5 Sayı: 1
  • Basım Tarihi: 1993
  • Doi Numarası: 10.1080/1120009x.1993.11739211
  • Dergi Adı: JOURNAL OF CHEMOTHERAPY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.56-59
  • Çukurova Üniversitesi Adresli: Hayır

Özet

This trial was carried out to assess the response rate and survival benefit achieved, if any, by substitution of etoposide for doxorubicin and addition of methotrexate in combination with cyclophosphamide and vincristine in the treatment of 113 patients with small cell lung carcinoma (SCLC). Cyclophosphamide, etoposide, vincristine, methotrexate (CEV-M) yielded a response rate of 75% in localized disease (LD) and 63% in extensive disease (ED), versus 61% in LD and 52% in ED in the cyclophosphamide, doxorubicin, vincristine (CAV) arm. There was also a significant survival benefit for the responders in favor of CEV-M (21.7 +/- 3.8 months of median survival compared to 13.6 +/- 2.8 months in CAV arm) in patients with LD.