Evaluation of the antitumor activity of a series of the pincer-type metallocomplexes produced from isonicotinohydrazide derivative.

Saygıdeğer Demir B., Mahmoudi G., Sezan A., Derinöz E., Nas E., Saygideger Y., ...Daha Fazla

Journal of inorganic biochemistry, cilt.223, ss.111525, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 223
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1016/j.jinorgbio.2021.111525
  • Dergi Adı: Journal of inorganic biochemistry
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, Chemical Abstracts Core, Chimica, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.111525
  • Anahtar Kelimeler: Antitumor activity, Cytotoxicity, Apoptosis, Pincer type complexes, Isonicotinohydrazone, Crystal structure, IN-VITRO, DNA-BINDING, LEAD(II) ARCHITECTURES, BIOLOGICAL EVALUATION, COORDINATION POLYMER, ANTICANCER ACTIVITY, METAL-COMPLEXES, IRON CHELATORS, HEPATOCELLULAR-CARCINOMA, HYDRAZONE COMPLEXES
  • Çukurova Üniversitesi Adresli: Evet

Özet

In this work we report on the antitumor properties of a series of pincer-type metallocomplexes [Hg-2(HL-keto)Cl-4](n) (1), [Hg(HL-keto)I-2] (2) and [Mn(HL-zwitterion)Cl-2]center dot MeOH (3 center dot MeOH), derived from N'-(1-(pyridin-2-yl) ethylidene)isonicotinohydrazide (HL) and corresponding metal salts. The Hg(II) and Mn(II) salts are chelated by the keto (HL-keto) or zwitterionic (HL-zwitterion) form of HL, respectively. The cytotoxic effects of these compounds have been accessed against lung adenocarcinoma (A549) and hepatocellular carcinoma (HepG2 and Huh7) cell lines. Complexes 1 and 2 were found to be most efficient against the cell line Huh7 with IC50 value of 2.56 and 9.90 mu M, respectively, while they exhibit moderate activity towards cell lines A549 and HepG2, as evidenced from IC50 values in the range 27.98-56.99 mu M. Complex 3 center dot MeOH is less efficient towards all the three cell lines with relatively high IC50 values. The mechanisms of the metallocomplexes killing the aforementioned cells were elucidated by flow cytometry, colony formation and polymerase chain reaction (PCR) analysis of apoptosis related expression of the genes. The results of the cytotoxic effects and antitumor activity on different cell lines are affected by the metal nature and the presence of the coordinated halide.