Targeting the PANoptosome with 3,4-Methylenedioxy-beta-Nitrostyrene, Reduces PANoptosis and Protects the Kidney against Renal Ischemia-Reperfusion Injury

Uysal, Erdal; DOKUR, MEHMET; Kucukdurmaz, Faruk; Altinay, Serdar; POLAT, SAİT; BATÇIOĞLU, KADİR; Sezgin, Efe; Ercakalli, TUĞÇE; Yaylali, Asli; YILMAZTEKİN, YAKUP; Cetin, Zafer; Saygili, Ilker; Barut, Osman; Kazimoglu, Hatem; MARALCAN, GÖKTÜRK; Koc, Suna; Guney, Turkan; Eser, Nadire; Sokucu, Mehmet; Dokur, Sema

doi:10.1080/08941939.2022.2128117

Targeting the PANoptosome with 3,4-Methylenedioxy-beta-Nitrostyrene, Reduces PANoptosis and Protects the Kidney against Renal Ischemia-Reperfusion Injury

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Uysal E., DOKUR M., Kucukdurmaz F., Altinay S., POLAT S., BATÇIOĞLU K., ...More

JOURNAL OF INVESTIGATIVE SURGERY, vol.35, no.11-12, pp.1824-1835, 2022 (SCI-Expanded)

Publication Type: Article / Article
Volume: 35 Issue: 11-12
Publication Date: 2022
Doi Number: 10.1080/08941939.2022.2128117
Journal Name: JOURNAL OF INVESTIGATIVE SURGERY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EBSCO Legal Collection, EBSCO Legal Source, EMBASE, MEDLINE
Page Numbers: pp.1824-1835
Keywords: PANoptosis, PANoptosome, 3,4-methylenedioxy-beta-nitrostyrene, ischemia, renal, OXIDATIVE STRESS, ISCHEMIA/REPERFUSION INJURY, NLRP3 INFLAMMASOME, INHIBITION, ACTIVATION, PYROPTOSIS, NUCLEAR
Çukurova University Affiliated: Yes

Abstract

Objectives: The objectives of this study were a) to investigate the effect of targeting the PANoptosome with 3,4-methylenedioxy-beta-nitrostyrene (MNS) on PANoptosis in the Renal ischemia-reperfussion (RIR) model b) to investigate the kidney protective effect of MNS toward RIR injury.