Quercetin and Cinnamaldehyde Show Antipathogenic Activity Against Proteus mirabilis Isolates: Inhibition of Swarming Motility and Urease Activity

AYGÜL A., KİBAR F., Ciragil P.

FLORA INFEKSIYON HASTALIKLARI VE KLINIK MIKROBIYOLOJI DERGISI, vol.25, no.1, pp.76-83, 2020 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 25 Issue: 1
  • Publication Date: 2020
  • Doi Number: 10.5578/flora.69001
  • Journal Name: FLORA INFEKSIYON HASTALIKLARI VE KLINIK MIKROBIYOLOJI DERGISI
  • Journal Indexes: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Page Numbers: pp.76-83
  • Keywords: Proteus mirabilis, Quercetin, Cinnamaldehyde, Swarming motility, Urease activity, URINARY-TRACT-INFECTIONS, IDENTIFICATION, EXPRESSION, VIRULENCE
  • Çukurova University Affiliated: Yes

Abstract

Introduction: Antipathogenic molecules target not the vital structures but the virulence factors of pathogenic microorganisms to prevent the development of an infection. Proteus mirabilis is a right candidate for testing antipathogenic molecules due to its distinctive features as an uropathogen such as spreading on urinary catheter surfaces by swarming motility, forming crystalline biofilm by intense urease activity and causing kidney stones.