The effect of levetiracetam on neuronal apoptosis in neonatal rat model of hypoxic ischemic brain injury

Kilicdag H., Daghoglu K. , ERDOĞAN Ş. , Guzel A., SENCAR L. , POLAT S. , ...More

EARLY HUMAN DEVELOPMENT, vol.89, no.5, pp.355-360, 2013 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 89 Issue: 5
  • Publication Date: 2013
  • Doi Number: 10.1016/j.earlhumdev.2012.12.002
  • Title of Journal : EARLY HUMAN DEVELOPMENT
  • Page Numbers: pp.355-360

Abstract

Background: Hypoxic-ischemic brain injury (HIBI) is a common cause of neonatal mortality and morbidity. The use of levetiracetam (LEV), as a potential neuroprotective in brain ischemia, receives an increasingly high attention, and it could have a crucial role in the regulation of epileptogenesis and neuroprotection. Potential effects of LEV on neuronal apoptosis in HIBI have not previously been reported in literature.