The effect of levetiracetam on neuronal apoptosis in neonatal rat model of hypoxic ischemic brain injury

Kilicdag H., Daghoglu K., ERDOĞAN Ş., Guzel A., SENCAR L., POLAT S., ...More

EARLY HUMAN DEVELOPMENT, vol.89, no.5, pp.355-360, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 89 Issue: 5
  • Publication Date: 2013
  • Doi Number: 10.1016/j.earlhumdev.2012.12.002
  • Journal Name: EARLY HUMAN DEVELOPMENT
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.355-360
  • Keywords: Levetiracetam, Apoptosis, Hypoxia, Ischemia, Brain injury, ANTIEPILEPTIC DRUGS, SEIZURES, NEURODEGENERATION, ENCEPHALOPATHY, TOPIRAMATE, PROTECTION, EXPOSURE
  • Çukurova University Affiliated: Yes

Abstract

Background: Hypoxic-ischemic brain injury (HIBI) is a common cause of neonatal mortality and morbidity. The use of levetiracetam (LEV), as a potential neuroprotective in brain ischemia, receives an increasingly high attention, and it could have a crucial role in the regulation of epileptogenesis and neuroprotection. Potential effects of LEV on neuronal apoptosis in HIBI have not previously been reported in literature.