The effect of levetiracetam on neuronal apoptosis in neonatal rat model of hypoxic ischemic brain injury

Kilicdag H., Daghoglu K., ERDOĞAN Ş., Guzel A., SENCAR L., POLAT S., ...Daha Fazla

EARLY HUMAN DEVELOPMENT, cilt.89, sa.5, ss.355-360, 2013 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 89 Sayı: 5
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1016/j.earlhumdev.2012.12.002
  • Dergi Adı: EARLY HUMAN DEVELOPMENT
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.355-360
  • Anahtar Kelimeler: Levetiracetam, Apoptosis, Hypoxia, Ischemia, Brain injury, ANTIEPILEPTIC DRUGS, SEIZURES, NEURODEGENERATION, ENCEPHALOPATHY, TOPIRAMATE, PROTECTION, EXPOSURE
  • Çukurova Üniversitesi Adresli: Evet

Özet

Background: Hypoxic-ischemic brain injury (HIBI) is a common cause of neonatal mortality and morbidity. The use of levetiracetam (LEV), as a potential neuroprotective in brain ischemia, receives an increasingly high attention, and it could have a crucial role in the regulation of epileptogenesis and neuroprotection. Potential effects of LEV on neuronal apoptosis in HIBI have not previously been reported in literature.