Novel vic-dioximes: Synthesis, complexation with transition metal ions, spectral studies and biological activity

Kurtoglu M., Ispir E., Kurtoglu N., Serin S.

DYES AND PIGMENTS, vol.77, no.1, pp.75-80, 2008 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 77 Issue: 1
  • Publication Date: 2008
  • Doi Number: 10.1016/j.dyepig.2007.03.010
  • Title of Journal : DYES AND PIGMENTS
  • Page Numbers: pp.75-80


A novel, substituted disodium-4-hydroxy-5- ( [(1 E,2E)-N-hydroxy-2-(hydroxyimino)ethanimidoyl]amino) naphthalene-2,7-disulfonate vic-dioxime ligand (LH2) was synthesized from 4-amino-5-hydroxy-2,7-naphthalenedisulfonic acid disodium salt and (E,E)-monochloroglyoxime at room temperature. The mononuclear Cu-II, Ni-II, Zn-II and Cd-II complexes of this vic-dioxime ligand were prepared and their structures confirmed by elemental analysis, IR and UV-visible spectroscopy; the H-1 and C-13 NMR spectra of the LH2 ligand (1) were also recorded. The oxime ligand, LH2, acts as a bidentate ligand bending through nitrogen atoms in the presence of base. Elemental analyses indicated that the ligand:metal ratio was 2:1 in the cases of Cu-II and Ni-II complexes and 1: 1 in the cases of Zn-II and Cd-II complexes. The ligand was screened for its antimicrobial activity against the fungi Rhodotorula rubra, Kluyveromyces marxianus, Aspergillus fumigatus and Mucor pusillus and this was compared to that of metal complexes derived from it. (C) 2007 Elsevier Ltd. All rights reserved.