Changes in nitric oxide level and superoxide dismutase activity during antimanic treatment

Gergerlioglu, H.; Savas, Haluk; Bulbul, FERİDUN; Selek, Salih; Uz, Efkan; Yumru, Mehmet

doi:10.1016/j.pnpbp.2006.12.020

Changes in nitric oxide level and superoxide dismutase activity during antimanic treatment

Atıf İçin Kopyala

Gergerlioglu H. S., Savas H. A., Bulbul F., Selek S., Uz E., Yumru M.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, cilt.31, sa.3, ss.697-702, 2007 (SCI-Expanded)

Yayın Türü: Makale / Derleme
Cilt numarası: 31 Sayı: 3
Basım Tarihi: 2007
Doi Numarası: 10.1016/j.pnpbp.2006.12.020
Dergi Adı: PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.697-702
Çukurova Üniversitesi Adresli: Hayır

Özet

Oxidant nitric oxide (NO) and antioxidant superoxide dismutase (SOD) have been implicated to play a role in the pathogenesis of bipolar disorders. This is the first prospective study aimed to evaluate NO levels and SOD activity in bipolar disorder (type I manic episode) (BD-ME). 29 inpatient subjects with BD-ME and 30 healthy controls were included. Serum NO levels and SOD activity have been studied at 1st (NO [1st] and SOD [1st] respectively) and 30th days (NO [30th] and SOD [30th] respectively) after treatment. The clinical outcome was measured by Bech-Rafaelson Mania Scale (BRMS). The mean NO [1st] (p <.001) and NO [30th] levels (p <.00 1) were higher than controls, but SOD [ I st] (p <.001) and SOD [30th] (p <.001) activities in BD-ME were lower than controls. SOD1 activity was higher than SOD [30th] (p <.001), while there was no significance in comparison between NO [1st] and NO [30th] (p <.05).