Nociceptive Effects of Locally Treated Metoprolol

Cukadar N., Baran F., Ozsoy K. E. , Uyanik F. B. , Surer T., MERT T., ...Daha Fazla

CUKUROVA MEDICAL JOURNAL, cilt.40, sa.2, ss.258-266, 2015 (ESCI İndekslerine Giren Dergi) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 40 Konu: 2
  • Basım Tarihi: 2015
  • Sayfa Sayıları: ss.258-266


Purpose: Beta (beta-)-adrenergic receptor antagonists, such as metoprolol, are often used to avoid circulatory complications during anesthesia for their antihypertensive and anti-tachycardia effects in patients with cardiovascular diseases. Although a few previous studies have been reported to exert antinociceptive and anesthetic effects of these drugs, knowledge about their action mechanisms in nociceptive process including pain perception is limited. This study therefore designed to identify the roles underlying the probable anti or hyper nociceptive effects of metoprolol, a beta-adrenergic receptor antagonist. In addition, effects of metoprolol were compared the dobutamin, a beta-adrenergic agonist.