Nociceptive Effects of Locally Treated Metoprolol

Cukadar N., Baran F., Ozsoy K. E. , Uyanik F. B. , Surer T., MERT T., ...More

CUKUROVA MEDICAL JOURNAL, vol.40, no.2, pp.258-266, 2015 (Journal Indexed in ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 40 Issue: 2
  • Publication Date: 2015
  • Page Numbers: pp.258-266


Purpose: Beta (beta-)-adrenergic receptor antagonists, such as metoprolol, are often used to avoid circulatory complications during anesthesia for their antihypertensive and anti-tachycardia effects in patients with cardiovascular diseases. Although a few previous studies have been reported to exert antinociceptive and anesthetic effects of these drugs, knowledge about their action mechanisms in nociceptive process including pain perception is limited. This study therefore designed to identify the roles underlying the probable anti or hyper nociceptive effects of metoprolol, a beta-adrenergic receptor antagonist. In addition, effects of metoprolol were compared the dobutamin, a beta-adrenergic agonist.