EVALUATION OF DICLOFENAC SODIUM INJECTION INDUCED NEUROPATHY


KAYA K. , Alizade A.

ACTA MEDICA MEDITERRANEA, vol.38, no.1, pp.733-739, 2022 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 38 Issue: 1
  • Publication Date: 2022
  • Doi Number: 10.19193/0393-6384_2022_1_114
  • Title of Journal : ACTA MEDICA MEDITERRANEA
  • Page Numbers: pp.733-739
  • Keywords: Injection injury, injection neuropathy, nerve injury, PAIN, INJURIES, RAT

Abstract

Background: Injection neuropathy is becoming a widespread health problem with increasing incidence in Turkey as well as in developing countries and causing high morbidity. It is seen that every day, the number of files sent by the judicial authorities for evaluation with the claim of medical malpractice is increasing. The aim of the present study is to investigate neuropathic damage or drug-induced neurotoxic effects that may occur due to injection applied to the gluteal region. Materials and methods: In this study, with the aim of investigating the neuropathic damage or drug-induced neurotoxic effects due to injection applied to the gluteal region; no injection was administered to the control group, intramuscular and intraneuronal injections were made to the sham and drug groups, and all mice were subjected to the Rotarod, Tail-flick, Cold Plate and Von Frey tests. Results: In all four test models, it was observed that there was a significant difference between the groups that received intraneuronal administration and the groups that received intramuscular administration (P<0.001). In almost all tests performed at the end of 24 hours, it was observed that the test results of the control and intramuscular administration groups were similar among themselves, and the intraneuronal administration groups were similar to each other. Conclusions: Sciatic neuropathy can cause an extensive range of damage, from the minor motor and sensory abnormalities to complete paralysis. The pathological effects of injection-related injuries vary with the injected agent. Intramuscular administrations usually do not cause nerve damage or nerve damage is minimally limited. Intraneuronal injection applications cause minimal to severe nerve damage depending on various factors. For the prevention of injection neuropathy, it should be ensured to develop proper health education policies and to conduct studies to determine the effects of the drugs found to cause injection neuropathy on the sciatic nerve toxicity.