Synthesis and Cytotoxic Activities of Difluoro-Dimethoxy Chalcones


Yamali C. , GÜL H. İ. , Ozgun D. O. , Sakagami H., Umemura N., KAZAZ C., ...More

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, vol.17, no.10, pp.1426-1433, 2017 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 10
  • Publication Date: 2017
  • Doi Number: 10.2174/1871520617666170327123909
  • Title of Journal : ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
  • Page Numbers: pp.1426-1433

Abstract

Background: Although anticancer chemotherapeutics are available in markets, side effects related to the drugs in clinical use lead to researchers to investigate new drug candidates which are more safe, potent and selective than others. Chalcones are popular with their anticancer activities with the several reported mechanisms including inhibition of angiogenesis, inhibition of tubulin polymerization, and induction of apoptosis etc.