Synthesis and Cytotoxic Activities of Difluoro-Dimethoxy Chalcones

Yamali C., GÜL H. İ., Ozgun D. O., Sakagami H., Umemura N., KAZAZ C., ...Daha Fazla

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, cilt.17, sa.10, ss.1426-1433, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Sayı: 10
  • Basım Tarihi: 2017
  • Doi Numarası: 10.2174/1871520617666170327123909
  • Dergi Adı: ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1426-1433
  • Anahtar Kelimeler: Chalcone, cytotoxicity, dimethoxy, difluoro, potency selectivity expression, dental cells, PARP, MOLECULAR TARGET PERSPECTIVES, MANNICH BASE DERIVATIVES, CARBONIC-ANHYDRASE I, CANCER CELLS, INHIBITORS, ACETYLCHOLINESTERASE, APOPTOSIS
  • Çukurova Üniversitesi Adresli: Hayır

Özet

Background: Although anticancer chemotherapeutics are available in markets, side effects related to the drugs in clinical use lead to researchers to investigate new drug candidates which are more safe, potent and selective than others. Chalcones are popular with their anticancer activities with the several reported mechanisms including inhibition of angiogenesis, inhibition of tubulin polymerization, and induction of apoptosis etc.