A pheochromocytoma case in a 6-year - old sheep

Aydogan A., Ozmen O.

REVUE DE MEDECINE VETERINAIRE, vol.163, no.11, pp.536-538, 2012 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 163 Issue: 11
  • Publication Date: 2012
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.536-538
  • Çukurova University Affiliated: No


Pheochromocytomas, rare in all species except rats, dogs and cattle, are neuroendocrine tumours of adrenal chromaffin cells. This case reports the occurrence of a tan-coloured mass in medulla of the left adrenal gland in a 6 - year - old female sheep dead from pneumonia. Histopathologically, the tumour was composed by pleomorphic cells with marked nuclei and abundant eosinophil cytoplasm. Immunohistochemistry evidenced expression of neuron specific enolase (NSE) and S100 protein in neoplastic cells associated with a strong Ki-67 activity. This tumour was diagnosed as pheochromocytoma. This is the first report of a pheochromocytoma in a sheep.