Copy For Citation
ÖZEN A. O., Kasap N., Vujkovic-Cvijin I., Apps R., Cheung F., Karakoc-Aydiner E., ...More
NATURE IMMUNOLOGY, vol.22, no.2, pp.128-151, 2021 (SCI-Expanded)
-
Publication Type:
Article / Article
-
Volume:
22
Issue:
2
-
Publication Date:
2021
-
Doi Number:
10.1038/s41590-020-00830-z
-
Journal Name:
NATURE IMMUNOLOGY
-
Journal Indexes:
Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE, Veterinary Science Database
-
Page Numbers:
pp.128-151
-
Çukurova University Affiliated:
Yes
Abstract
CHAPLE disease is a lethal syndrome caused by genetic loss of the complement regulatory protein CD55. Lenardo, Ozen and their colleagues report that blockade of C5 complement activation in a small cohort of pediatric patients with CHAPLE disease reduced gastrointestinal pathology and restored their immunity and growth.