Spiro(pyrrolidinyl-2,3'-benzodiazepines) related to MK-329
TETRAHEDRON, cilt.52, sa.42, ss.13455-13466, 1996 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 52 Sayı: 42
- Basım Tarihi: 1996
- Doi Numarası: 10.1016/0040-4020(96)00806-x
- Dergi Adı: TETRAHEDRON
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.13455-13466
- Çukurova Üniversitesi Adresli: Hayır
Özet
Imines of 1-ethyl-3-amino-1,3-dihydro-5-phenyl-(2H)-1,4-benzodiazepine-2-one undergo thermal (toluene, 110 degrees C) or LiBr-DBU catalysed (MeCN, room temperature) regio- and stereo-specific cycloaddition to a range of achiral and chiral dipolarophiles giving racemic and homochiral spiro (pyrrolidinyl-2,3'-benzodiazepine) cycloadducts respectively in excellent yield. The reactions proceed via intermediate NH azomethine ylides and lithe azomethine ylides respectively. Copyright (C) 1996 Elsevier Science Ltd