Preoperative Immunonutrition and Postoperative Outcomes in Radical Pancreaticoduodenectomy Patients


ABA M., SARITAŞ A. G., YAVUZ B., DALCI K., ÜLKÜ A., AKÇAM A. T.

Turkish Journal of Gastroenterology, cilt.35, sa.1, ss.32-40, 2024 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 35 Sayı: 1
  • Basım Tarihi: 2024
  • Doi Numarası: 10.5152/tjg.2023.22793
  • Dergi Adı: Turkish Journal of Gastroenterology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, MEDLINE, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.32-40
  • Çukurova Üniversitesi Adresli: Evet

Özet

Background/Aims: This study aimed to compare the patient groups who received and did not receive immunonutrition in terms of mor- tality and morbidity in patients who underwent radical pancreaticoduodenectomy. Materials and Methods: Two groups were formed from 40 patients who underwent radical pancr eaticoduodenectomy in our clinic in 2021. The patients in study group were given enteral immunonutrition support for 5 days preoperatively. For this purpose, a standard enteral immunonutrition product containing arginine, omega-3 fatty acids, and RNA (dietary nucleotides) was used. Patients’ data of demographical, laboratory, postoperative complications, and current clinical status were analyzed. Result: Mortality developed in 5 (25 %) patients in the treatment group and 4 (20 %) patients in the control group in the following months (P > .05). The estimated survival rate in the treatment group was 21.8 ± 2.8 months in the treatment group 19.1 ± 1.7 months in the control group (P > .05). The length of hospital stay was 12.89 ± 3.3 days in the treatment group, while it was 16.47 ± 6.83 days in the control group (P < .05). In the postoperative follow-ups, delayed gastric emptying symptoms developed in 3 patients in the treat- ment group, while the same complication was observed in 9 patients in the control group (P < .05). Surgical site infections occurred in 4 patients in the treatment group and 9 patients in the control group (P < .05). Conclusion: It was observed that preoperative oral immunonutrition before pancreaticoduodenectomy was effective in reducing the risk of delayed gastric emptying after surgery and the length of hospital stay.