Effects of two different lipid emulsions on antioxidant status, lipid peroxidation and parenteral nutrition- related cholestasis in premature babies, a randomized-controlled study

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Yıldızdas H., Poyraz B., Atlı G., Sertdemir Y., Mert K., Ozlu F., ...More

PEDIATRICS AND NEONATOLOGY, vol.60, pp.359-367, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 60
  • Publication Date: 2019
  • Doi Number: 10.1016/j.pedneo.2018.07.012
  • Journal Name: PEDIATRICS AND NEONATOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.359-367
  • Keywords: cholestasis, fish oil/MCT/olive oil/soy bean lipid, olive oil/soybean lipid, preterm, FISH-OIL, PRETERM INFANTS, CLINICAL-TRIAL, DOCOSAHEXAENOIC ACID, DOUBLE-BLIND, OLIVE OIL, RISK, OMEGA-3-FATTY-ACIDS, RETINOPATHY, ENZYMES
  • Çukurova University Affiliated: Yes

Abstract

Background: Olive oil-soybean oil (OO/SO) based lipid emulsions (LE) lack omega-3 PUFAs eicosapentaenoic acid -EPA and docosahexaenoic acid- DHA, which have clinical benefits on inflammatory processes. Fish oil based LEs are good sources of DHA and EPA. Fish oil, MCT, Olive oil and Soya oil (FMOS) lipid is one of the fish oil containing LEs supplemented with high levels of alpha-tocopherol and lower levels of phytosterol compared to OO/SO lipid emulsions. We investigated the effects of OO/SO and FMOS lipid preparations on cholestasis, levels of antioxidant enzymes and lipid peroxidation.