Solid phase sequential 1,3-dipolar cycloaddition-Pictet-Spengler reactions

DÖNDAŞ H. A., Grigg R., MacLachlan W., MacPherson D., Markandu J., Sridharan V., ...More

TETRAHEDRON LETTERS, vol.41, no.6, pp.967-970, 2000 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 41 Issue: 6
  • Publication Date: 2000
  • Doi Number: 10.1016/s0040-4039(99)02183-8
  • Journal Name: TETRAHEDRON LETTERS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.967-970
  • Keywords: cycloaddition, Pictet-Spengler reaction, Pd catalysis, cascade reaction, HIGHLY FUNCTIONALIZED PYRROLIDINES, COMBINATORIAL CHEMISTRY, ORGANIC-SYNTHESIS, SUPPORT
  • Çukurova University Affiliated: No

Abstract

Up to six bonds and two rings can be created, in five component processes (five points of diversity), by AgOAc catalysed imine cycloaddition to Wang resin acrylate followed by Pictet-Splengler and Pd(0) catalysed reactions. (C) 2000 Elsevier Science Ltd. All rights reserved.