N-terminal heterogenicity of amyloid protein examined in Alzheimer's disease


Pirim I., Erdogan A., Tan U.

INTERNATIONAL JOURNAL OF NEUROSCIENCE, cilt.114, ss.75-81, 2004 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 114 Konu: 1
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1080/00207450490249455
  • Dergi Adı: INTERNATIONAL JOURNAL OF NEUROSCIENCE
  • Sayfa Sayısı: ss.75-81

Özet

Alzheimer's disease is the major cause of dementia in humans. The affected brain shows characteristic abnormal filamentous proteins that accumulate intracellularly as neurofibrillary tangles, and extracellularly as senile plaques, as well as in cerebral blood vessels. The extracellular deposits are an amyloid protein, which is highly insoluble. In our study, we intended to show that the N-terminus of amyloid A4 protein can change in length and sequence in Alzheimer's disease, and possibly in other dementias.