Diabetes insipidus (DI) is a disorder characterized by polyuria, polydipsia and increased thirst  while pituitary DI is a syndrome that is known to result from deficient release of the antidiuretic hormone (ADH) [2,3]. Trauma to the neurohypophysis (operational or accidental) is the most common cause of DI. Primary or metastatic intracranial tumors are the second most common cause of DI. Among the less frequent causes are the granulomatous lesions or infections of the central nervous system, drugs and vascular lesions . In 30-40% of the patients, there is no identifiable cause (idiopathic DI). Idiopathic thrombocytopenic purpura (ITP) is an immunologically mediated destructive thrombocytopenia. The clinical diagnosis is made after excluding the presence of other disorders that are known to be associated with shortened platelet survival . In this paper two cases of DI and ITP are described.