In vitro effect of trimetazine on K-Cl cotransport and superoxide dismutase activity in Hemoglobin SS erythrocytes

Guvenc B., Unsal C., Menziletoglu S., Gurkan E., Nevruz O., Guvenc H.

PERIODICUM BIOLOGORUM, cilt.107, sa.2, ss.231-234, 2005 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 107 Sayı: 2
  • Basım Tarihi: 2005
  • Dergi Adı: PERIODICUM BIOLOGORUM
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.231-234
  • Çukurova Üniversitesi Adresli: Hayır

Özet

Background and Purpose: Trimetazidine (TMZ) (1-2,3,4 trimethoxybenzyl piperazine dihydrochloride) is a cyto-productive agent which is used as an anti-anginal drug. Sickle Cell Anemia (SCA) is characterized by increased K-Cl cotransport (KCC) activity and self-generated free radicals. The aim of study was to investigate the effect of TMZ on KCC activity and free radicals in SCA patients.