In vitro effect of trimetazine on K-Cl cotransport and superoxide dismutase activity in Hemoglobin SS erythrocytes


Guvenc B., Unsal C., Menziletoglu S. , Gurkan E., Nevruz O., Guvenc H.

PERIODICUM BIOLOGORUM, vol.107, no.2, pp.231-234, 2005 (Journal Indexed in SCI) identifier

  • Publication Type: Article / Article
  • Volume: 107 Issue: 2
  • Publication Date: 2005
  • Title of Journal : PERIODICUM BIOLOGORUM
  • Page Numbers: pp.231-234

Abstract

Background and Purpose: Trimetazidine (TMZ) (1-2,3,4 trimethoxybenzyl piperazine dihydrochloride) is a cyto-productive agent which is used as an anti-anginal drug. Sickle Cell Anemia (SCA) is characterized by increased K-Cl cotransport (KCC) activity and self-generated free radicals. The aim of study was to investigate the effect of TMZ on KCC activity and free radicals in SCA patients.