Protective effects of tempol in an experimental ovarian ischemia-reperfusion injury model in female Wistar albino rats


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Pinar N., KARAPINAR O. S. , ÖZCAN O., Dogan E. A. , Bayraktar S.

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, vol.95, no.7, pp.861-865, 2017 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 95 Issue: 7
  • Publication Date: 2017
  • Doi Number: 10.1139/cjpp-2016-0309
  • Title of Journal : CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
  • Page Numbers: pp.861-865

Abstract

The aim of this study was to investigate the antioxidant effects of tempol on ovarian ischemia-reperfusion (I/R) injury in rats. Forty female Wistar albino rats were randomly divided into 5 groups: Group I, sham; Group II, ischemia (I); Group III, I/R; Group IV, I/R + tempol 30 mg/kg i.p; Group V, I/R + tempol 50 mg/kg i.p. Oxidative stress index (OSI) was significantly higher in the ischemia group and the I/R group than in the sham group. Catalase levels were significantly lower in the I/R group than in the I/R + tempol 30 mg/kg i.p. and the I/R + tempol 50 mg/kg i.p. groups. Glutathione peroxidase levels were lower in the I/R group than in the I/R + tempol 30 mg/kg i.p. and the I/R + tempol 50 mg/kg i.p. groups. MDA levels were significantly lower in the I/R + tempol 30 mg/kg i.p. group and the I/R + tempol 50 mg/kg i.p. group than in the I/R group. The levels of the histopathological parameters were significantly decreased in the I/R + tempol 50 mg/kg i.p. group compared with the I/R group. Tempol can be used for reducing ovarian I/R injury.