Protective Effect Of Hypericum Perforatum Extract On Gentamicin Induced Ototoxicity

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KAPLAN H. M.

GAZI MEDICAL JOURNAL, cilt.28, sa.1, ss.8-10, 2017 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 28 Sayı: 1
  • Basım Tarihi: 2017
  • Doi Numarası: 10.12996/gmj.2017.03
  • Dergi Adı: GAZI MEDICAL JOURNAL
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.8-10
  • Anahtar Kelimeler: Gentamicin, ototoxicity, Hypericum perforatum, rotarod and motor coordination, ARACHIDONIC-ACID RELEASE, NF-KAPPA-B, GUINEA-PIGS, FLAVONOIDS, INHIBITION, HYPERFORIN, AMENTOFLAVONE, SUPPRESSION, ACTIVATION
  • Çukurova Üniversitesi Adresli: Hayır

Özet

Objective: Hypericum perforatum, which have various names locally such as "sari kantaron, kanotu, kilicotu, mayasilotu, yaraotu", is a plant which blooms between july and september at farms, borders of roads and woods, top of hills and grasslands, whose anti-inflammatory and antioxidant effects are shown in various studies. Due to this reason, we planned a study to examine the protective effects of Hypericum perforatum on ototoxicity caused by gentamicin.