Abdominal Paragangliomas: A Single Center Experience


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Sarıtaş A. G. , Gül M. O. , Yalav O. , Teke Z., Güney İ. B.

Bezmiâlem Science, cilt.0, no.0, 2020 (Diğer Kurumların Hakemli Dergileri)

Özet

Objective: Paragangliomas are rare tumors arising from extra-adrenal

chromaffin tissue, which are widely distributed near or within the

autonomic nervous system in the retroperitoneal sites and in the

sympathetic ganglia of various viscera. We present a review of our 18-

year institutional experience with resected abdominal paragangliomas.

Methods: The data collected from 12 patients who underwent surgery

due to abdominal paraganglioma in our clinic between 2002 and 2020

were analyzed retrospectively.

Results: There were 12 patients in our study. The median age was

44 years (range: 21-81 years). The patients had one or more of the

symptoms of headache (n:2, 16,6%), palpitations, abdominal pain

(n:5, 41.6%), sweating (n:2, 16.6%) and hypertension (n:5, 41.6%),

which are the classic clinical symptoms. One of the cases (1/12; 8,3%)

was detected incidentally. The mass location was in the retroperitoneal

region in 10 cases (83.3%) and in the pelvic region in 2 cases (16.6%).

Five of the patients applied to our clinic with episodes of paroxysmal

hypertension, and vanillylmandelic acid and metanephrine levels were

found to be high in the blood and 24-h urinary tests. After a median

follow-up period of 60 months, only 1 patient (8.3%) had metastasis

and required reoperation 2 years after the first operation. One patient

(8.3%) died on postoperative 36th month due to cardiac problems.

Conclusion: Abdominal paragangliomas are rare tumors whose

optimal management requires the surgeon to be highly attentive to

the disease course, from diagnosis of functioning or nonfunctioning

lesions, through operative treatment that may require adjacent organ

resection, to lifelong follow-up for recurrences.

Keywords: Paraganglioma, Endocrine hypertension, Retroperitoneal,

Metastasis, Surgical treatment, Survival