Reliability of essential oils and their nano-formulations against Anopheles stephensi (Liston): A comprehensive review and in silico approach
South African Journal of Botany, cilt.186, ss.391-412, 2025 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Derleme
- Cilt numarası: 186
- Basım Tarihi: 2025
- Doi Numarası: 10.1016/j.sajb.2025.09.026
- Dergi Adı: South African Journal of Botany
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, Veterinary Science Database
- Sayfa Sayıları: ss.391-412
- Anahtar Kelimeler: Anopheles stephensi, Essential oils, In silico, Life cycle, Malaria, Terpenes
- Çukurova Üniversitesi Adresli: Evet
Özet
Malaria is a deadly vector-borne disease, with a high rate of mortality that poses a global public health issue. As such, it is imperative to better understand the physiological targets of vectors in order to discover new molecules and compounds to limit its propagation. Essential oils (EOs) as plant-derived products constitute a significant approach against mosquitos. This review aims to clarify the importance of these substances and their components to control Anopheles stephensi. We included data and generalities about this insect, its epidemiological status, an overview of its life cycle, the EO's mechanism of action, and an in silico study of their molecular targets. Information was collected from the following online scientific databases: ScienceDirect, Google scholar, Web of Science, and Scopus. Seventy-two species belonging to 17 families have been reported as a potential bio-insecticide against An. stephensi. Monoterpenes and sesquiterpenes are the main classes in the reported EOs. EOs have several molecular targets, including proteins, nucleic acids, bio-membranes, and many cellular components. Also, they exhibit an impact on the inhibition of Acetylcholinesterase (AChE) and the "GABA-gated" chloride channel, as well as the disruption of Na-K ion exchange and constriction of cellular respiration. An in silico study showed promising results of these compounds on acetylcholinesterase, chitin synthase-2, and juvenile hormone. Based on the data presented in this review, EOs provide a safe alternative to synthetic insecticide and can be used to limit the propagation of these mosquitos and the transmission of malaria.