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van der Zanden L. F. M., van Rooij I. A. L. M., Quaedackers J. S. L. T., Nijman R. J. M., Steffens M., de Wall L. L. L., ...More
EUROPEAN UROLOGY OPEN SCIENCE, vol.28, pp.26-35, 2021 (SCI-Expanded)
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Publication Type:
Article / Article
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Volume:
28
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Publication Date:
2021
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Doi Number:
10.1016/j.euros.2021.04.001
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Journal Name:
EUROPEAN UROLOGY OPEN SCIENCE
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Journal Indexes:
Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE, Directory of Open Access Journals
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Page Numbers:
pp.26-35
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Keywords:
CDH12, Genome-wide association study, Obstructive uropathy, Posterior urethral valves, RENAL EXPRESSION, HUMAN PANCREAS, NEPHROPATHY, TGF-BETA-1, PROMOTES, CHILDREN
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Çukurova University Affiliated:
Yes
Abstract
Background: Posterior urethral valves (PUVs) and ureteropelvic junction obstruction (UPJO) are congenital obstructive uropathies that may impair kidney development. Objective: To identify genetic variants associated with kidney injury in patients with obstructive uropathy. Design, setting, and participants: We included 487 patients born in 1981 or later who underwent pyeloplasty or valve resection before 18 yr of age in the discovery phase, 102 PUV patients in a first replication phase, and 102 in a second replication phase.