CDH12 as a Candidate Gene for Kidney Injury in Posterior Urethral Valve Cases: A Genome-wide Association Study Among Patients with Obstructive Uropathies

van der Zanden, Loes; van Rooij, Iris; Quaedackers, Josine; Nijman, Rien; Steffens, Martijn; de Wall, Liesbeth; Bongers, Ernie; Schaefer, Franz; Kirchner, Marietta; Behnisch, Rouven; Bayazit, AYSUN; Caliskan, Salim; Obrycki, Lukasz; Montini, Giovanni; Duzova, Ali; Wuttke, Matthias; Jennings, Rachel; Hanley, Neil; Milmoe, Natalie; Winyard, Paul; Renkema, Kirsten; Schreuder, Michiel; Roeleveld, Nel; Feitz, Wout

doi:10.1016/j.euros.2021.04.001

CDH12 as a Candidate Gene for Kidney Injury in Posterior Urethral Valve Cases: A Genome-wide Association Study Among Patients with Obstructive Uropathies

van der Zanden L. F. M., van Rooij I. A. L. M., Quaedackers J. S. L. T., Nijman R. J. M., Steffens M., de Wall L. L. L., ...Daha Fazla

EUROPEAN UROLOGY OPEN SCIENCE, cilt.28, ss.26-35, 2021 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 28
Basım Tarihi: 2021
Doi Numarası: 10.1016/j.euros.2021.04.001
Dergi Adı: EUROPEAN UROLOGY OPEN SCIENCE
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE, Directory of Open Access Journals
Sayfa Sayıları: ss.26-35
Anahtar Kelimeler: CDH12, Genome-wide association study, Obstructive uropathy, Posterior urethral valves, RENAL EXPRESSION, HUMAN PANCREAS, NEPHROPATHY, TGF-BETA-1, PROMOTES, CHILDREN
Çukurova Üniversitesi Adresli: Evet

Özet

Background: Posterior urethral valves (PUVs) and ureteropelvic junction obstruction (UPJO) are congenital obstructive uropathies that may impair kidney development. Objective: To identify genetic variants associated with kidney injury in patients with obstructive uropathy. Design, setting, and participants: We included 487 patients born in 1981 or later who underwent pyeloplasty or valve resection before 18 yr of age in the discovery phase, 102 PUV patients in a first replication phase, and 102 in a second replication phase.