Protective Effect of Proanthocyanidin against Methotrexate-Induced Testicle Damage in Rats


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YÜNCÜ M., Zengin G., BİRİNCİ H., BOSTANCIERİ N., POLAT S.

EUROPEAN JOURNAL OF THERAPEUTICS, vol.25, no.1, pp.51-57, 2019 (Journal Indexed in ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 25 Issue: 1
  • Publication Date: 2019
  • Doi Number: 10.5152/eurjther.2018.790
  • Title of Journal : EUROPEAN JOURNAL OF THERAPEUTICS
  • Page Numbers: pp.51-57

Abstract

Objective: Methotrexate (MTX) isawidely used chemotherapeutic agent showing side effects such as hepatotoxicity and also testicular damage due to an increase in the production of reactiveoxygen species. Proanthocyanidins (PACs) are known as natural antioxidants that have protective effects against oxidative stress. This study investigates the protective effect of PAC against the MTX-induced testicular damage.