EUROPEAN JOURNAL OF THERAPEUTICS, vol.25, no.1, pp.51-57, 2019 (ESCI)
Objective: Methotrexate (MTX) isawidely used chemotherapeutic agent showing side effects such as hepatotoxicity and also testicular damage due to an increase in the production of reactiveoxygen species. Proanthocyanidins (PACs) are known as natural antioxidants that have protective effects against oxidative stress. This study investigates the protective effect of PAC against the MTX-induced testicular damage.