Haemodiafiltration does not lower protein-bound uraemic toxin levels compared with haemodialysis in a paediatric population


Snauwaert E., Van Biesen W., Raes A., Glorieux G., Vande Walle J., Roels S., ...More

NEPHROLOGY DIALYSIS TRANSPLANTATION, vol.35, no.4, pp.648-656, 2020 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 35 Issue: 4
  • Publication Date: 2020
  • Doi Number: 10.1093/ndt/gfz132
  • Title of Journal : NEPHROLOGY DIALYSIS TRANSPLANTATION
  • Page Numbers: pp.648-656

Abstract

Background. Haemodiafiltration (HDF) is accepted to effectively lower plasma levels of middle molecules in the long term, while data are conflicting with respect to the additive effect of convection on lowering protein-bound uraemic toxins (PBUTs). Here we compared pre-dialysis beta 2-microglobulin (beta 2M) and PBUT levels and the percentage of protein binding (%PB) in children on post-dilution HDF versus conventional high- (hf) or low-flux (lf) haemodialysis (HD) over 12 months of treatment.