Haemodiafiltration does not lower protein-bound uraemic toxin levels compared with haemodialysis in a paediatric population

Snauwaert E., Van Biesen W., Raes A., Glorieux G., Vande Walle J., Roels S., ...Daha Fazla

NEPHROLOGY DIALYSIS TRANSPLANTATION, cilt.35, sa.4, ss.648-656, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 35 Sayı: 4
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1093/ndt/gfz132
  • Dergi Adı: NEPHROLOGY DIALYSIS TRANSPLANTATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.648-656
  • Anahtar Kelimeler: child, end-stage kidney disease, haemodiafiltration, protein-bound uraemic toxins, HIGH-FLUX HEMODIALYSIS, VOLUME ONLINE HEMODIAFILTRATION, CHRONIC KIDNEY FAILURE, ALL-CAUSE MORTALITY, P-CRESOL, EXTENDED HEMODIALYSIS, TREATMENT TOLERANCE, REMOVAL, DIALYSIS, SOLUTES
  • Çukurova Üniversitesi Adresli: Evet

Özet

Background. Haemodiafiltration (HDF) is accepted to effectively lower plasma levels of middle molecules in the long term, while data are conflicting with respect to the additive effect of convection on lowering protein-bound uraemic toxins (PBUTs). Here we compared pre-dialysis beta 2-microglobulin (beta 2M) and PBUT levels and the percentage of protein binding (%PB) in children on post-dilution HDF versus conventional high- (hf) or low-flux (lf) haemodialysis (HD) over 12 months of treatment.