Haemodiafiltration does not lower protein-bound uraemic toxin levels compared with haemodialysis in a paediatric population


Snauwaert E., Van Biesen W., Raes A., Glorieux G., Vande Walle J., Roels S., ...Daha Fazla

NEPHROLOGY DIALYSIS TRANSPLANTATION, cilt.35, ss.648-656, 2020 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 35 Konu: 4
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1093/ndt/gfz132
  • Dergi Adı: NEPHROLOGY DIALYSIS TRANSPLANTATION
  • Sayfa Sayıları: ss.648-656

Özet

Background. Haemodiafiltration (HDF) is accepted to effectively lower plasma levels of middle molecules in the long term, while data are conflicting with respect to the additive effect of convection on lowering protein-bound uraemic toxins (PBUTs). Here we compared pre-dialysis beta 2-microglobulin (beta 2M) and PBUT levels and the percentage of protein binding (%PB) in children on post-dilution HDF versus conventional high- (hf) or low-flux (lf) haemodialysis (HD) over 12 months of treatment.