Recent Insights in Multi-Target Drugs in Pharmacology and Medicinal Chemistry

Cemali S. H., POYRAZ S., Belveren S., Taş S., Tamer M. A., YAKTUBAY DÖNDAŞ N., ...Daha Fazla

ChemMedChem, 2025 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Derleme
  • Basım Tarihi: 2025
  • Doi Numarası: 10.1002/cmdc.202500447
  • Dergi Adı: ChemMedChem
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Agricultural & Environmental Science Database, BIOSIS, Biotechnology Research Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE
  • Anahtar Kelimeler: cancer, molecular docking, multitargeted drugs, neurodegenerative diseases, synthesis methods
  • Çukurova Üniversitesi Adresli: Evet

Özet

Many of the drugs used in treatment today have been designed based on the “specificity paradigm”. Resistance has developed against drugs designed using this approach, leading to a decrease in their effectiveness. In addition, it is well-documented in the literature that diseases with complex etiologies, such as Alzheimer's, Parkinson's, and cancer are influenced by multiple genetic and/or environmental factors. As a result, specificity paradigm is often insufficient for treating these diseases. Therefore, there is a need to develop drugs that interact with multiple targets simultaneously through different mechanisms. This review aims to provide an overview of the methods used in multitarget drug design, the reactions employed in the synthesis of these drugs, their applications, and recent research conducted in this field.