Sixteen privately owned dogs with generalized demodicosis included in this study. For the treatment of generalized demodicosis, tablet form of ivermectin (Efektin tablet (R) 10 mg, Sanovel) at a dose of 600 mu g kg(-1) daily was used in study dogs for 6-22 weeks. lvermectin was used at least for 2 weeks more after no mites (dead or alive) seen. All dogs had significant reduction in the in clinical signs and number of mites on skin scrapings during re-evaluations. All dogs became skin scrapings negative. After no mites were seen, treatment was continued for 2 more weeks and then stopped. But three dogs relapsed 5, 8 and 9 months after the therapy lasted. Remained 13 dogs were negative for skin scrapings and clinically normal after 12 months. Oral ivermectin, at a dosage of 600 mu g kg(-1), PO, daily, was found to be effective in resolving generalized demodicosis in 13 of 16 dogs (82,25%.) in one year follow-up after discontinuing of therapy. Although, there were some literatures evaluating the efficacy of the use of injectable formula of ivermectin, to the present authors' knowledge these is the first report evaluating tablet form of ivermectin in the treatment of canine demodicosis.