In this study, salinity and drought responses of 65 watermelon genotypes have been investigated in early plant growth stage. The plants were grown in vermiculite culture with 200 mM NaCl for salinity stress and irrigation was stopped gradually for terminal-drought stress. Control plants without stress have also been grown. Young plants (24 days old plant) were used for screening studies. Physiological measurements and analysis were conducted to identify tolerant versus susceptible watermelon genotypes; A scale evaluation of 0-5 for symptomatic appearance of the plants, shoot fresh and dry weights, root fresh and dry weights, leaf number per plant, leaf area, SPAD-Chlorophyll meter reading, membrane injury index, leaf relative water content, leaf water potential, leaf osmotic potential, stomata conductance, leaf temperature, Na, K, Ca, and Cl concentrations of the shoot and root samples. For each parameter, differences in salinity and drought stresses compared to control have been calculated. At the end of the study, large variations have been determined in watermelon genotypes for their salinity and drought responses. The sixty-five watermelon genotypes were classified as tolerant, mildly tolerant or susceptible.