Akademik Veri Yönetim Sistemi
ASIAN JOURNAL OF SOCIAL PSYCHOLOGY, cilt.274, ss.1-6, 2012 (SSCI)
(MD), and may provide a valuable clue to the identification of target loci and successful search for major
genes. In order to identify chromosomal regions we aimed to detect the relationships between
chromosomal aberrations (CAs) and immunological markers in a family with MD and psoriasis. We used
the cell cultivation and conventional G-banding. We found predominantly numerical aberrations. The most
common aneuploidy was chromosome 8, followed by chromosome 22, 21, 15, X and Y. However, structural
aberrations consisted of duplications, deletions, translocations and breaks, with a focus on: loci on
del(1)(q12–q23), del(1)(q21.1–q24), del(1)(q21.1–q23), del(10)(p11.2-pter), der(2)t(2;4)(p25;p12),
t(2;22)(p14;p13), t(19;Y)? and dup(10)(q26). The susceptibility genes of MD or psoriasis may be located
on these loci. Numerical sex CAs included 4(5.8%) with 45,X, 3(4.3%) with 47,XXY, and 4(5.8%) with
structural chromosome X; del(X)(q13); del(X)(p11-pter) del(X)(q21.3) and inv(Y)(q11.2). We also
conducted an immunological study. According results of this study, the percentage of CD2+, CD4+ and CD8+
lymphocytes of the father were significantly higher, whereas CD4+ lymphocytes were decreased in the
mother, when compared the healthy persons. The percentage of CD4 level of the son was decreased,
whereas CD8+ lymphocytes were higher. The CD4/CD8 ratio of the father and the son was found to be
significantly high. These results may suggest that MD and psoriasis have a significant impact on both
genetic and immunological parameters.