Effects of trimetazidine on tissue damage in kidney after hindlimb ischemia-reperfusion


Sucu N., Unlu A., Tamer L., AYTACOGLU B., COSKUN B., Bilgin R. , et al.

PHARMACOLOGICAL RESEARCH, cilt.46, ss.345-349, 2002 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 46 Konu: 4
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1016/s104366180200172x
  • Dergi Adı: PHARMACOLOGICAL RESEARCH
  • Sayfa Sayısı: ss.345-349

Özet

The objective of this study was to investigate the effects of trimetazidine (TMZ) on tissue damage in kidney after hindlimb ischemia-reperfusion (I/R), by assessing blood biochemical assay and histopathological analysis. Adult male Wistar rats were divided into two groups. TMZ 10 mg kg(-1) day(-1) was administrated twice a day for 10 days to the treatment group (group T, n = 10). Sham group was given only 5% gum arabic (group S, n = 10). On 11th day of treatment, 8 h I/R period was performed on right hindlimb of the rats. At the end of reperfusion period, a 5 ml blood withdrawn from ascending aorta for biochemical assays and their right kidneys were harvested for histopathological examination. Superoxide dismutase, Na+-K+ ATPase, and reduced glutathione levels were significantly increased in group T (P < 0.001). On the other hand, myeloperoxidase and malondialdehyde levels were significantly less in group T than group S (P < 0.001). Kidneys from the sham-operated group displayed intense leukocytic infiltration in histopathological examination.