The changes of erythrocyte membrane Na+-K+ ATPase activities in subjects with normal and impaired glucose tolerance

Bilgin R. , Tukel S.

BIOCHEMICAL ARCHIVES, vol.12, no.3, pp.149-156, 1996 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 12 Issue: 3
  • Publication Date: 1996
  • Title of Journal : BIOCHEMICAL ARCHIVES
  • Page Numbers: pp.149-156


The effects of glucose on Na+-K+ ATPase activity of erythrocyte membranes were investigated under in vitro and in vivo conditions. Results of the study, in vitro, showed that Na+-K+ ATPase activity of erythrocyte membrane was increased by increasing glucose concentrations (0-30 mM). When glucose-6-phosphate (0-100 mM) was used instead of glucose no significant change occured in Na+-K+ ATPase activity. Tunicamycin (0.01 ng/ml) when added to the incubation media together with glucose prevented the increase in Na+-K+ ATPase activity.